home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410o.zip
/
M94A2872.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
2KB
|
39 lines
Document 2872
DOCN M94A2872
TI Two cases of AIDS associated with hemophilia A, treated effectively by
the concomitant use of SNMC and ddI.
DT 9412
AU Mori K; Sendai Hematologic Clinic, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):205 (abstract no. PB0251). Unique
Identifier : AIDSLINE ICA10/94369703
AB OBJECTIVE: We studied a combination therapy using glycyrrhizin (Stronger
Neo-Minophagen C: SNMC) which has been shown to be effective against HIV
at an ultra-high dose by a different mechanism from that of AZT and ddI.
SUBJECTS AND METHODS: The patients were 43 year-old and 41 year-old
brothers with hemophilia A complicated by AIDS. In addition to routine
examinations (1) CD4 positive lymphocyte count and CD4/CD8 ratio (flow
cytometry) (2) HIV antigen and HIV antibody (Dainabot Kit) were
measured. RESULTS: HIV antigen levels decreased and changed to negative
54 weeks in case 1 and 12 weeks in case 2 after the initiation of SNMC
and ddI. HIV p24 antibody, which was negative before initiation of this
therapy, became positive after 82 weeks and 14 weeks, respectively, and
gradually increased. CD4 positive lymphocyte count also increased from
68/microliters to 262/microliters and from 362/microliters to
700/microliters, respectively. DISCUSSION AND CONCLUSIONS: Now, the
patients maintained still good condition as AC at the time of 160 weeks
and 140 weeks, respectively. We think that this favorable results were
due to concomitant use of high-dose SNMC and ddI, as different types of
anti-HIV drugs.
DE Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS/*DRUG THERAPY
Adult Antiviral Agents/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE Case
Report Didanosine/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE Drug
Evaluation Drug Therapy, Combination Glycyrrhetinic Acid/*ANALOGS &
DERIVATIVES/ADMINISTRATION & DOSAGE/THERAPEUTIC USE
Hemophilia/COMPLICATIONS Human HIV Antibodies/BLOOD HIV
Antigens/BLOOD Leukocyte Count Male Treatment Outcome T4 Lymphocytes
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).